I am not sure why you would ever want to do this except probably if you do not have a windows enabled keyboard but here is the tip anyway (tip for the sack of tip !!!!). To disable use of Win key, open registry by going to START-RUN and entering regedit. Navigate to

[HKEY_LOCAL_MACHINE\\SYSTEM\\CurrentControlSet\\Control\\Keyboard Layout] . In this look for value of "Scancode Map". Its binary data so be extra careful:

Set its value to "00 00 00 00 00 00 00 00 03 00 00 00 00 00 5B E0 00 00 5C E0 00 00 00 00" to disable the win key.